AZD-1152 C26H31FN7O6P structure

C26H31FN7O6P structure
Molecular Formula C26H31FN7O6P
Average mass 587.540 Da
Density 1.5±0.1 g/cm3
Boiling Point
Flash Point
Molar Refractivity 150.8±0.3 cm3
Polarizability 59.8±0.5 10-24cm3
Surface Tension 73.6±3.0 dyne/cm
Molar Volume 401.4±3.0 cm3
  • Experimental Physico-chemical Properties
  • Miscellaneous
    • Bio Activity:

      Aurora Kinase MedChem Express HY-10127
      AZD1152 (barasertib), pro-drug of barasertib-hQPA(HY-10126), is a selective Aurora B kinase inhibitor, AZD1152 inhibited the proliferation various types of human leukemia cells with an IC50 ranging f
      rom 3 nM to 40 nM. MedChem Express
      AZD1152 (barasertib), pro-drug of barasertib-hQPA(HY-10126), is a selective Aurora B kinase inhibitor, AZD1152 inhibited the proliferation various types of human leukemia cells with an IC50 ranging from 3 nM to 40 nM.; IC50 value: 3-40 nM (HL-60, NB4, MOLM13; PALL-2; MV4-11; EOL-1; K562 cell) [1]; Target: Aurora B kinase; in vitro: AZD1152, a highly selective inhibitor of Aurora B kinase, on various types of human leukemia cells. MedChem Express HY-10127
      AZD1152 (barasertib), pro-drug of barasertib-hQPA(HY-10126), is a selective Aurora B kinase inhibitor, AZD1152 inhibited the proliferation various types of human leukemia cells with an IC50 ranging from 3 nM to 40 nM.;IC50 value: 3-40 nM (HL-60, NB4, MOLM13; PALL-2; MV4-11; EOL-1; K562 cell) [1];Target: Aurora B kinase;In vitro: AZD1152, a highly selective inhibitor of Aurora B kinase, on various types of human leukemia cells. AZD1152 inhibited the proliferation of AML lines (HL-60, NB4, MOLM13), ALL line (PALL-2), biphenotypic leukemia (MV4-11), acute eosinophilic leukemia (EOL-1), and the blast crisis of chronic myeloid leukemia K562 cells with an IC50 ranging from 3 nM to 40 nM, as measured by thymidine uptake on day 2 of culture [1]. The selective Aurora B inhibitor AZD1152-induced apoptotic death in myeloma cell lines at nanomolar concentrations, with a cell cycle phenotype consistent with that reported previously for Aurora B inhibition [3]. AZD1152 exerted antiproliferative MedChem Express HY-10127
      Cell Cycle/DNA Damage MedChem Express HY-10127
      Cell Cycle/DNA Damage; MedChem Express HY-10127

Predicted data is generated using the ACD/Labs Percepta Platform – PhysChem Module

Density: 1.5±0.1 g/cm3
Boiling Point:
Vapour Pressure:
Enthalpy of Vaporization:
Flash Point:
Index of Refraction: 1.675
Molar Refractivity: 150.8±0.3 cm3
#H bond acceptors: 13
#H bond donors: 5
#Freely Rotating Bonds: 15
#Rule of 5 Violations: 3
ACD/LogP: 1.71
ACD/LogD (pH 5.5): -1.74
ACD/BCF (pH 5.5): 1.00
ACD/KOC (pH 5.5): 1.00
ACD/LogD (pH 7.4): -2.26
ACD/BCF (pH 7.4): 1.00
ACD/KOC (pH 7.4): 1.00
Polar Surface Area: 185 Å2
Polarizability: 59.8±0.5 10-24cm3
Surface Tension: 73.6±3.0 dyne/cm
Molar Volume: 401.4±3.0 cm3

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