Lomitapide C39H37F6N3O2 structure

C39H37F6N3O2 structure
Molecular Formula C39H37F6N3O2
Average mass 693.720 Da
Density 1.3±0.1 g/cm3
Boiling Point 778.2±60.0 °C at 760 mmHg
Flash Point 424.4±32.9 °C
Molar Refractivity 178.4±0.4 cm3
Polarizability 70.7±0.5 10-24cm3
Surface Tension 52.9±5.0 dyne/cm
Molar Volume 517.3±5.0 cm3
  • Experimental Physico-chemical Properties
  • Miscellaneous
    • Bio Activity:

      Lomitapide(AEGR-733; BMS-201038) is an inhibitor of microsomal triglyceride-transfer protein (MTP) wtih in vitro IC50 of 8 nM. MedChem Express
      Lomitapide(AEGR-733; BMS-201038) is an inhibitor of microsomal triglyceride-transfer protein (MTP) wtih in vitro IC50 of 8 nM.; IC50 value: 8 nM [1]; Target: MTP inhibitor; Lomitapide is a small-molecule, microsomal triglyceride transfer protein (MTP) inhibitor, for the treatment of both familial and primary hypercholesterolemia. MedChem Express HY-14667
      Lomitapide(AEGR-733; BMS-201038) is an inhibitor of microsomal triglyceride-transfer protein (MTP) wtih in vitro IC50 of 8 nM.;IC50 value: 8 nM [1];Target: MTP inhibitorLomitapide is a small-molecule, microsomal triglyceride transfer protein (MTP) inhibitor, for the treatment of both familial and primary hypercholesterolemia. Oral, once-daily lomitapide will be targeted at patients resistant to HMG-CoA reductase inhibitors (statins) either due to abnormalities in liver function or to discontinuation because of muscle pain. MedChem Express HY-14667
      Others MedChem Express HY-14667

Predicted data is generated using the ACD/Labs Percepta Platform – PhysChem Module

Density: 1.3±0.1 g/cm3
Boiling Point: 778.2±60.0 °C at 760 mmHg
Vapour Pressure: 0.0±2.7 mmHg at 25°C
Enthalpy of Vaporization: 113.2±3.0 kJ/mol
Flash Point: 424.4±32.9 °C
Index of Refraction: 1.606
Molar Refractivity: 178.4±0.4 cm3
#H bond acceptors: 5
#H bond donors: 2
#Freely Rotating Bonds: 12
#Rule of 5 Violations: 2
ACD/LogP: 7.78
ACD/LogD (pH 5.5): 4.49
ACD/BCF (pH 5.5): 296.67
ACD/KOC (pH 5.5): 297.86
ACD/LogD (pH 7.4): 5.86
ACD/BCF (pH 7.4): 7065.37
ACD/KOC (pH 7.4): 7093.64
Polar Surface Area: 61 Å2
Polarizability: 70.7±0.5 10-24cm3
Surface Tension: 52.9±5.0 dyne/cm
Molar Volume: 517.3±5.0 cm3

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