Effects on Acidity

Group 1 effects
+R +I
Group 2 effects
-R +I
Group 3 effects
-R -I
what’s in group I?
directly attached to carbonyl (C=O)
Nitriles
Halogens
-CF3
Quat Salt (N+-R3)
what’s in group 2?
lone pairs
what’s in group 3?
alkyl groups
aromatic
CO2-
Meta:
Inductive
Para:
resonance
x

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