Exam 3 Biochem-Lecture 28

 

Desaturation of Fatty Acids requires combination of

  • desaturase enzyme
  • cytochrome b5
  • NADPH-cytochrome b5 reductase

Triacylglycerols are synthesized from:

  • Fatty Acyl CoAs
  • Glycerol 3-Phosphate

 

The first step  of Synthesis of Triacylglycerols is formation of  ……?

phosphatidic  acid.

Fatty acyl CoAs are formed ….?
outside mitochondria
What is the transport molecule for fatty acids into the mitochondrial matrix???
Carnitine

 

FAS are oxidized sequentially how many carbons at a time???

 

FAS are oxidized sequentially 2 carbons at a time.

Sequential steps of  Fatty Acid b-Oxidation are:

 

  1. Dehydrogenation
  2. Hydration
  3. Oxidation
  4. Cleavage

 

Fatty Acid b-Oxidation is Oxidized while attached as:

 

as a thioester to 4-phosphopantetheine of CoA

Overall yield of  Fatty Acid b-Oxidation is

 

106 ATPS.

 

b-oxidation oxidizes saturated fatty acids with even or odd number???

 

b-oxidation oxidizes saturated fatty acids with even number

In Fatty Acid Oxidation, Odd-chains produces
propinolyl CoA

 

•In Fatty acid Oxidation, Unsaturated fatty acids require ….?

additional enzymes
In Fatty Acid Oxidation, a– oxidation is necessary for

  • for metabolism  of branched chain fatty acid
  • uses fatty acid a hydroxylase
  • occurs in peroxisomes

Ketone Bodies

  • an alternate fuel for cells
  • Water soluble lipid based energy

Ketone Bodies formation occurs
 in the mitochondrial matrix
 bhydroxybmethylglutaryl CoA (HMG-CoA) is intermediate in
 bhydroxybmethylglutaryl CoA (HMG-CoA) is intermediate in acetoacetate synthesis from acetyl-CoA.

In Ketone Body synthesis, 

2 acetyl-CoA molecules are condensed

to form ……………by bketothiolase.

In Ketone Body synthesis,   

2 acetyl-CoA molecules are condensed

to form acetoacetyl-CoA by bketothiolase.

In Ketone Bodies synthesis, Acetoacetyl-CoA is condensed with a second acetyl-CoA to form HMG-CoA by what????

In Ketone Bodies synthesis, Acetoacetyl-CoA is condensed with a second acetyl-CoA to form HMG-CoA by HMG-CoA synthase.

In Ketone Bodies synthesis, what is condensed with a second acetyl-CoA to form HMG-CoA by HMG-CoA synthase???

In Ketone Bodies synthesis, Acetoacetyl-CoA is condensed with a second acetyl-CoA to form HMG-CoA by HMG-CoA synthase.

In Ketone Bodies synthesis, Acetoacetyl-CoA is condensed with what to form HMG-CoA by HMG-CoA synthase.???

In Ketone Bodies synthesis, Acetoacetyl-CoA is condensed with a second acetyl-CoA to form HMG-CoA by HMG-CoA synthase.

In Ketone Bodies synthesis, Acetoacetyl-CoA is condensed with a second acetyl-CoA to form what by HMG-CoA synthase???

In Ketone Bodies synthesis, Acetoacetyl-CoA is condensed with a second acetyl-CoA to form HMG-CoA by HMG-CoA synthase.

 

HMG-CoA is cleaved by HMG-CoA lyase

to yield

  • acetoacetic acid 
  •  acetyl-CoA.

 

Acetoacetic acid is reduced to dbhydroxy

butyrate by b-hyrdoxybutyrate dehydrogenase to yield hydroxybutyrate at the expense of how many NADH??.

 

Acetoacetic acid is reduced to dbhydroxy

butyrate by b-hyrdoxybutyrate dehydrogenase to yield hydroxybutyrate at the expense of 1 NADH.

 

What is reduced to dbhydroxy

butyrate by b-hyrdoxybutyrate dehydrogenase to yield hydroxybutyrate at the expense of 1 NADH???

 

Acetoacetic acid is reduced to dbhydroxy

butyrate by b-hyrdoxybutyrate dehydrogenase to yield hydroxybutyrate at the expense of 1 NADH.

 

Acetoacetic acid is reduced to what by b-hyrdoxybutyrate dehydrogenase to yield hydroxybutyrate at the expense of 1 NADH???

 

Acetoacetic acid is reduced to dbhydroxy

butyrate by b-hyrdoxybutyrate dehydrogenase to yield hydroxybutyrate at the expense of 1 NADH.

 

Acetoacetic acid spontaneously forms

  • acetone
  • + CO2.

 

Absence of HMG-CoA lyase results in HMG-CoA being used for ???

cholesterol synthesis
Ketone Bodies can be used by

Brain

Muscle

Other tissues

BUT NOT LIVER(Liver can not use ketone bodies)

 

x

Hi!
I'm Larry

Hi there, would you like to get such a paper? How about receiving a customized one?

Check it out