Exam 3 Liver Function

Where does metabolic activity takes place at?
Within hepatocytes
_______ deliver blood from the hepatic artery
Sinusoids
What type of cells ingest bacteria/foreign materials?
Kupffer’s cells
(Macrophages)
What are the ducts that drain fluid called?
Canaliculi
What is the functioning unit of the liver called?
Lobule
True or False:
Ducts merge to form the common bile duct
True
List the Functions of the Liver (4-5)
Excretory/Secretory
Synthesis
Detoxification
Storage
What is the major heme waste product?
Bilirubin
What is the amount of bilirubin that is produced daily?
200-300 mg
What is the Normal Total Adult Bilirubin level in the Plasma?
0.2-1.2 mg/dL
What is most of the normal total adult bilirubin made of?
Unconjugated
What is the following considered:
RBC Destruction –> Heme –> Bilirubin –> +Albumin –> Unconjugated Bilirubin
Indirect
What are all of the following examples of:
Result of RBC lysis (2-3 hours)
Albumin-bound
Indirect
Not Water Soluble
Not Excretable
Unconjugated
What are all of the following examples of:
Formed in liver from unconjugated
Direct
Water soluble
Excretable
Converts to urobilinogen
Conjugated
Name the disease:
Yellowish pigmentation in skin, eyes, and mucous membranes
Jaundice
Jaundice will be apparent when bilirubin levels react what in the plasma?
2-3 mg/dL
What do the following describe:
Increased Indirect
Normal Direct
No bilirubin in urine
Overproduction of bilirubin NOT associated with liver dysfunction
Prehepatic Jaundice
What do the following describe:
Defective cellular uptake, transport, conjugation, or secretion
Hepatic Jaundice
What do the following describe:
Obstruction of bile flow to kidneys
Positive Urine Bilirubin
Negative Urine Urobilinogen
Posthepatic Jaundice
The following diseases are associated with which type of Jaundice?
Hemolytic anemias, transfusion reactions, sickle cell anemia, HDN
Prehepatic Jaundice
What can HDN lead to?
Pathological Jaundice of the newborn
What can you treat Kernicterus with?
Transfusion and/or phototherapy
How soon will Physiological Jaundice of the newborn resolve?
7-10 days
Breast Milk Jaundice is caused from interference of what 2 substances?
Pregnandiol or Progesterone
The following diseases are associated with which type of Jaundice?
Physiological jaundice of the newborn
Break milk jaundice
Cirrhosis, hepatitis, cancer
Drug-induced toxicity
Autoimmune Diseases
Reye’s
Hepatic Jaundice
Reye’s is associated with what levels or direct and indirect?
Increased Direct
Increased Indirect
What type of Jaundice are the following diseases/conditions associated with?
Gallstones, tumors, clay-colored stools
Posthepatic Jaundice
Which which type of Jaundice will you see an increase in the amount of bilirubin in the serum?
Posthepatic Jaundice
Which which type of Jaundice will you see an increase in the levels of GGT & ALP?
Posthepatic Jaundice
List 3 substances stored in the liver.
Glycogen
Iron
Vitamins
List the endproduct of protein metabolism that is formed in the liver
Urea
What type of hormones are produced in the liver?
Steroid
Match the substance with the description:
Water soluble bilirubin
Conjugated bilirubin
Match the substance with the description:
Normally found in the urine as a waste product
Urobilinogen
Match the substance with the description:
Direct bilirubin
Conjugated bilirubin
Match the substance with the description:
Formed as a result of RBC lysis
Unconjugated bilirubin
Match the substance with the description:
Albumin-bound
Unconjugated bilirubin
Match the substance with the description:
Bilirubin that is excretable into urine
Conjugated bilirubin
Match the substance with the description:
Formed in the liver under enzyme action
Conjugated bilirubin
Match the substance with the description:
Formed in the intestines under bacterial enzyme action
Urobilinogen
Match the type of jaundice with the condition:
Breast milk jaundice
Hepatic jaundice
Match the type of jaundice with the condition:
Gallstones
Posthepatic jaundice
Match the type of jaundice with the condition:
Viral hepatitis
Hepatic jaundice
Match the type of jaundice with the condition:
Hemolytic anemia
Prehepatic jaundice
Match the type of jaundice with the condition:
Cirrhosis
Hepatic jaundice
Match the type of jaundice with the condition:
Bile duct tumor
Posthepatic jaundice
Match the type of jaundice with the condition:
Hemolytic disease of the newborn
Prehepatic jaundice
Match the type of jaundice with the condition:
Physiologic jaundice of the newborn
Hepatic jaundice
At what bilirubin level in the serum will jaundice become evident?
>2 mg/dL
What term describes the deposit of bilirubin in the CNS of infants that may lead to brain damage and mental retardation?
Kernicterus