Exam 4 Chemistry Review/Study Questions Part 7

Match the drug with its proper class:
Cyclosporine
Immunosuppressive
Match the drug with its proper class:
Tacrolimus
Immunosuppressive
Match the drug with its proper class:
Vancomycin
Antibiotic
Match the drug with its proper class:
Aminoglycosides
Antibiotic
Match the drug with its proper class:
Lithium
Psychoactive
Match the drug with its proper class:
TCAs
Psychoactive
Match the drug with its proper class:
Digoxin
Cardioactive
Match the drug with its proper class:
Procainamide
Cardioactive
Match the drug with its proper class:
Phenobarbital
Antiepileptic
Match the drug with its proper class:
Phenytoin (Dilantin)
Antiepileptic
Match the drug with its proper class:
Methotrexate
Antineoplastic
Which drug can cause a drug-induced lupus?
Procainamide
Which drug can cause Ototoxicity?
Vancomycin and other antibiotics
Which drug can cause Bone marrow suppression?
Methotrexate
Which drug can cause Serious birth defects?
Thalidomide
For each of the following alcohols, state its final metabolite:
Ethanol
acetic acid
For each of the following alcohols, state its final metabolite:
Methanol
formic acid
For each of the following alcohols, state its final metabolite:
Isopropanol
acetone
For each of the following alcohols, state its final metabolite:
Ethylene glycol
glycolic and oxalic acid
What is the legal limit of intoxication for adults?
.08 g/dL (80 mg/dL)
What term describes the specific specimen collection, handling, and testing requirements for medicolegal cases?
Chain of custody
Which type of alcohol can cause blindness?
Methanol
Which type of alcohol can cause renal damage due to calcium oxalate crystal formation?
Ethylene glycol
Match the drug or compound with its characteristic:
Mixed acid-base disorder and platelet dysfunction
Salicylate
Match the drug or compound with its characteristic:
Accumulates in fat cells; detected weeks after exposure
Cannabinoids
Match the drug or compound with its characteristic:
Anti-anxiety drug; may be fatal when mixed with alcohol
Barbiturates
Match the drug or compound with its characteristic:
Blocks heme synthesis
Lead
Match the drug or compound with its characteristic:
Analgesic; causes liver failure 3-5 days post OD
Acetaminophen
Match the drug or compound with its characteristic:
The most commonly abused drug
Alcohol
Match the drug or compound with its characteristic:
Exposure usually through eating contaminated fish and seafood
Mercury
Match the drug or compound with its characteristic:
Derived from poppies; OD cause heart failure and myoglobinuria
Opiates
Match the drug or compound with its characteristic:
CNS stimulant related to ephedrine
Amphetamine
Match the drug or compound with its characteristic:
Toxicity due to exposure to pesticides; acetylcholinesterase test
Organophosphates
Match the drug or compound with its characteristic:
Replaces oxygen in hemoglobin, resulting in tissue hypoxia
Carbon monoxide
Match the drug or compound with its characteristic:
Testosterone-related compound causing liver damage and impotence
Anabolic steroids
Match the drug or compound with its characteristic:
Rat poison; interrupts cellular ATP production
Cyanide
Name 5 commonly performed tests that can help determine if a urine specimen is invalid
pH, SG, Creatinine, nitrite, temperature, glutaraldehyde
Define Toxicology
The study of poisons, their actions, detection and treatment of toxicity
Define Poison
any substance that causes a harmful effect (damage to cellular structure or function) upon exposure, whether ingested, inhaled, or absorbed
What Mechanism of Toxicity is connected to the following:
Organophosphates
Irreversible enzyme inhibition
What Mechanism of Toxicity is connected to the following:
Benzene/carcinogens
Interfere with DNA synthesis
What Mechanism of Toxicity is connected to the following:
Cyanide
Uncouple biochemical reactions
What Mechanism of Toxicity is connected to the following:
Carbon Monoxide
Block hemoglobin-oxygen transport
What Mechanism of Toxicity is connected to the following:
Aspirin
Exaggerated effects
Leading cause of auto-related fatalities
Ethanol
What may Ethanol poisoning/toxicity progress to?
Pancreatitis, Alcoholic hepatitis, Cirrhosis
True or False:
Alcohol – M
Metabolic acidosis, but the CNS depressant effect inhibits hyperventilation
True
With Ethanol poisoning/toxicity what is likely to be elevated?
GGT
(AST/ALT too)
What do you treat Methanol toxicity with?
Ethanol
What kind of effect will Isopropanol have?
Extended due to long half-life
Which type of alcohol is tied to Rapid formation of calcium oxalate crystals may cause tubular damage?
Ethylene glycol
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