MCMP 407 Final

Muscarine
Muscarine receptor no medical use, SLUD
ACh
M+N, intraocular use for miosis, SLUD
Carbachol
M+N, intraocular use for miosis, glaucoma, SLUD
Pilocarpine
M, Glaucoma, SLUD
Bethanechol
M, urinary retention, post operative ileus, SLUD
Chantix
Partial N agonsist, smoking cessation, SLUD
Edrophonium
Rev. AChE inh., Myassthenia Gravis, SLUD
Neostigmine
Reversible AChE, myasthenia gravis, glaucoma, post operative ileus, SLUD
Pyridostigmine
Rev. AChE inh., Myasthenia gravis, post op ileus, glaucoma, SLUD
Physostigmine
Reversible AChE, glaucoma, AD, antidote to anticholinergic OD, SLUD
Rivastigmine
Rev. AChE inh., glaucoma, AD, N&V, anorexia, weight loss
Isofluorophate
Irr. AChE inh. Glaucoma
Echothiophate
Irr. AChE inh., glaucoma
Tacrine
Rev. AChE inh. AD
Donepezil
Rev. AChE inh, AD
2-PAM
AChE poisoning antidoe
Memantine
NDMA rec. antagonist, AD
Reminyl
Rev. AChE inh., AD
Atropine
non-selective M antagonist, mydriatic, sedation, tachycardia, dry mouth
Scopolamine
M ant. sea sickness, ANTI SLUD
Homatropine
Non-selective M ant. topically to produce cycloplegia, anti-SLUD
Anistotropine
non-selective M ant. GI spasms and peptic ulcers, anti-slud
Glycopyrrolate
non-selective M ant. GI spasms and peptic ulcers, anti-SLUD
Topicamide
M in the eyes, mydriasis, anti SLUD
Ipratropium bromide
M3 rec ant., asthma of COPD, anti slud
Benztropine
anti-AChE and antihistamine effects, PD, anti-slud
Procyclidine
PD, Anti-slud
Tolterodine (detrol)
M ant. urinary incontinence, anti slud
Diphemanil
M ant., antispamodic, anti-slud
Benadryl
M ant., antihistamine, anti-slud
Imipramine
M. ant, TCA antidepressant, anti-slud
Vesamicol
Depletes ACh vesicles
Botox
Inhibits ACh release, old skin
Hemicholinium
Inhibits uptake of choline
Trimethaphan camphorsulfonate
Ganglionic (nicotinic) blocker, hypertensive crisis
Mescamylamine
Ganglionic (nicotinic) blocker, hypertensive crisis
d-tubocurarine
Nic. rec block at motor end plate, muscle relaxation during surgery
Pancuronium bromide
Nic. rec block at motor end plate, muscle relaxation during surgery
Vecuronium
Nic. rec block at motor end plate, muscle relaxation during surgery
Rocuronium
Nic. rec block at motor end plate, muscle relaxation during surgery
Atracurium
Nic. rec block at motor end plate, muscle relaxation during surgery
Mivacurium
Nic. rec block at motor end plate, muscle relaxation during surgery
Succinyl Choline
Nic. rec block at motor end plate, muscle relaxation during surgery
l-NE
alpha, b1, b2 agonist, pressor – dec HR
Epinephrine
alpha, B1, B2, anaphylaxis, glaucoma, local anestetics (adjunct), inc HR
Phenylephrine
alpha 1, mydriasis, glaucoma, pressor, nasal decongestant
Naphazoline
A1 partial agonist, decongestant
Visine
A1 partial agonist, decongestant
Afrin
A1 partial agonist, decongestant
Clonidine
A2 agonist, HTN, sedation, H20 retention, dry mouth
Guanabenz
A2 agonist, HTN, sedation, H20 retention, dry mouth
Guanfacine
A2 agonist, HTN, sedation, H20 retention, dry mouth
Methyldopa
A2 agonist, HTN, sedation, H20 retention, dry mouth
Apraclonidine
A2 agonist, glaucoma, sedation, H20 retention, dry mouth
Tizanidine
A2 agonist, muscle spasticity, sedation, H20 retention, dry mouth
Isoproterenol
non-selective beta agonist, asthma, COPD, cardiostimulant – inc HR
Dopamine
B1 receptor, critical life threatening situations
Terbutaline
B2 agonist, asthma, COPD, tocolytic
Metaproterenol
B2 agonist, asthma, COPD, tachycardia
Albuterol
B2 agonist, asthma, COPD, tachycardia
Salmeterol
B2 agonist, asthma, COPD, tachycardia
Formoterol
B2 agonist, asthma, COPD, tachycardia
Ritodrine
B2 agonist, tocolytic
Dobutamine
B1 agonist, acute heart failure, shock; + inotropic effect
Amphetamine
NET reverser, ADHD, narcolepsy
Ephedrine
Direct acting agonist, nasal decongestant, CTN: HTN
Pseudoephedrine
NET reverser, nasal decongestant, CTN: HTN
Cocaine
DAT blocker, tachycardia
Desipramine
Transport blocker, depression, ADD
Phenelzine
MAO inh., depression
Selegiline
MAO inh. early PD, depression
Phenoxybenzamine
A1, A2 ant. pheochromocytoma, HTN crisis, orthostatic hypotension, tachycardia
Phentolamine
A1, A2 ant. phenochromocytoma, HTN crisis, impotence, orthostatic hypotension, tachycardia
Prazosin
A1 ant. HTN and BPH, reflex tachycardia and orthostatic hypotension
Terazosin
A1 ant. HTN and BPH, reflex tachycardia and orthostatic hypotension
Doxazonsin
A1 ant. HTN and BPH, reflex tachycardia and orthostatic hypotension
Ergot alkaloids
A1, A2 ant, migraines, LSD effect
Yohimbine
A2 ant. impotence
Propranolol
B1, B2 ant. HTN, angina, migraine, glaucoma, CHF; bradycardia, AV block; CTN: asthma, COPD
Nadolol
B1, B2 ant. HTN, angina, migraine, glaucoma, CHF; bradycardia, AV block; CTN: asthma, COPD
Timolol
B1, B2 ant. HTN, angina, migraine, glaucoma, CHF; bradycardia, AV block; CTN: asthma, COPD
Pindolol
B1, B2 ant. HTN, angina, migraine, glaucoma, CHF; bradycardia, AV block; CTN: asthma, COPD
Carteolol
B1, B2 ant. HTN, angina, migraine, glaucoma, CHF; bradycardia, AV block; CTN: asthma, COPD
Toprol
B1 ant., HTN, angina, CHF, bradycardia, AV block, sedation CTN: asthma, COPD
Bisoprolol
B1 ant., HTN, angina; bradycardia, AV block, sedation CTN: asthma, COPD
Atenolol
B1 ant., HTN, angina; bradycardia, AV block, sedation CTN: asthma, COPD
Esmolol
B1 ant., HTN, angina; bradycardia, AV block, sedation CTN: asthma, COPD
Labetalol
B1 B2 A1 ant. HTN and HTN crisis, B-blocking prevents reflex tachycardia from A1 block
Carvediolol
B1, B2, A1 ant. HTN and CHF, B-blocking blocks reflex tach. from A block
alpha-methytrosine
Inh. NE synthesis, pheochromocytoma, EPS, orthostatic hypotension
Reserpine
deplete vesicular stores of NE, HTN, may be linked to depression
Bretylium Tosylate
NE release inhibitor, antiarrhythmic, CTN: pts with AV block
D-ephedrine
DA, NE, 5-HT releasing agent, decongestant
Methamphetamine
DA, NE, 5-HT releaser
Amphetamine
DA, NE, 5-HT releaser, ADHD
Ritalin
DA/NE reuptake inh., ADHD
Focalin
DA/NE reuptake inh. ADHD
Strattera
NET inh. ADHD
Provigil
Narcolepsy
Phentermine
NET blocker – appetite suppression
Benzpheramine
DAT/NET blocker, appetite suppression
Phenmetrazine
DAT/NET blocker, appetite suppression
Diethylpropion
DAT/NET blocker, appetite suppression
Meridia
SERT/NET inh. appetite suppressant
L-DOPA
PD
Sinemet (levadopa/carbidopa)
PD, inhibits decarboxylase in periphery
Apomorphine
D1/D2 ag. PD
Pramipexole
D2/D3 ag. PD
Requip
D2/D2 ag. PD
Pergolide
D2/D3 ag. PD
Bromocriptine
D2/D3 ag. PD
Rotigotine
D2/D3 ag. PD
Selegiline
Irr. MAO inh. PD
Rasagiline
Irr. MAO inh. PD
Entacapone
COMT inh. PD
Psilocybin
5-HT ag. Shrooms
DMT
5HT-2A
LSD
5HT2A most potent
Mescaline
5HT2A
Ectasy
5HT and DA release
THC
CB1 ag
PCP
NMDA blocker
Ketamine
NMDA blocker
Chloropromazine (Thorazine)
A1 and 5HT ag. 1st gen antipsychotic, EPS
Promethazine (Phenergan)
H1 ant. 1st gen antipsychotic
Thioridazine (Mellaril)
D2 ant. 1st gen antipsychotic
Fluphenazine
D2 ant. 1st gen antipsychotic, EPS
Prochlorperazine
D2 ant. 1st gen antipsychotic, EPS
Perphenazine
D2 ant. 1st gen antipsychotic, EPS
Thiothixene
D2 ant. 1st gen antipsychotic, EPS
Halperiodl
D2 ant. 1st gen antipsychotic, EPS
Molindone
D2 ant. 1st gen antipsychotic, EPS
Pimozide
D2 ant. 1st gen antipsychotic, EPS
Clozapine
5-HT2A>D2, atypical antipsychotic, less EPS, treats secondary symptoms
Olanzapine
5-HT2A>D2, atypical antipsychotic, less EPS, treats secondary symptoms
Loxapine
5-HT2A>D2, atypical antipsychotic, less EPS, treats secondary symptoms
Seroquel
5-HT2A>D2, atypical antipsychotic, less EPS, treats secondary symptoms
Risperione
5-HT2A>D2, atypical antipsychotic, less EPS, treats secondary symptoms
Ziprasidone (Geodon)
5HT, D2, A1 ant. atypical antipsychotic, less EPS, treats secondary symptoms
Abilify
5HT2 and D2 partial agonist, antipyschotic
Phenelzine
non-selective MAOI, antidepressant
Tranylcypromine
non-selective MAOI, antidepressant
Selegiline
MAOBI, antidepressant
Moclobemide
MAOAI, antidepressant
Imipramine
TCA – NET and SERT inh. antidepressant, can OD – tertiary amine
Amitriptyline
TCA – NET and SERT inh. antidepressant, can OD – tertiary amine
Doxepin
TCA – NET and SERT inh. antidepressant, can OD – tertiary amine
Trimipramine
TCA – NET and SERT inh. antidepressant, can OD – tertiary amine
Clomipramine
TCA – NET and SERT inh. antidepressant, can OD – tertiary amine
Desipramine
TCA – NET and SERT inh. antidepressant, can OD – secondary amine
Nortriptyline
secondary TCA – NET/SERT inh. can OD
Protriptyline
secondary TCA – NET/SERT inh. can OD
Maprotiline
secondary TCA – NET/SERT inh. can OD
Fluoxetine (Prozac)
SSRI – depression, OCD, PTSD
Fluvoxamine (Luvox)
SSRI – depression, OCD, PTSD
Paroxetine (Paxil)
SSRI – depression, OCD, PTSD
Sertaline (Zoloft)
SSRI – depression, OCD, PTSD
Citalopram (Celexa)
SSRI – depression, OCD, PTSD
Escitalopram (Lexapro)
SSRI – depression, OCD, PTSD
Amoxapine
D2 ant, NET inh. anitdepressant
Trazodone
5HT2 ant. antidepressant
Nefazodone
5HT2A ant. antidepressant
Bupropion (Wellbutrin)
DAT>NET=SERT inh. antidepressant
Mirtazapine
A2 ant, 5HT2, 5HT3, H1, ant. antidepressant
Venlafaxine (Effexor)
NET and SERT inh. SNRI, GAD, panic, depression
Duloxetine (Cymbalta)
NET/SERT inh. SNIR; GAD, depression
Reboxetine (Vestra)
NET inh. Depression, ADHD
Atomoxetine (Straterra)
NET inh. antidepressant, ADHD
Diazepam (Valium)
BZD; muscle spasms, sedation
Baclofen (Lioresal)
GABA-B ag. activates K+ channels, muscle relaxant
Tizanidine
A2 ag. works in reflex arc, muscle relaxant
Cyclobenzaprine
Acute muscle spasm, anitmuscarinic properties
Dantrolene
Reduces release of Ca++ from SR, cerebral palsy, MS, malignant hyperthermia
Succinylchonline
AChE, Neuromuscular blocks
Mivacurium
AChE, Neuromuscular blocks
Atracurium
AChE, Neuromuscular blocks
Vecuronium
AChE, Neuromuscular blocks
Rocuronium
AChE, Neuromuscular blocks
Pancuronium
AChE, Neuromuscular blocks
Ether
Activate K+, block Na+, disrupt membrane potential; inhaled anesthetics, malignant hyperthermia
Nitrous oxide
Activate K+, block Na+, disrupt membrane potential; inhaled anesthetics, malignant hyperthermia, FAST
Halothane
Activate K+, block Na+, disrupt membrane potential; inhaled anesthetics, malignant hyperthermia
Enflurane
Activate K+, block Na+, disrupt membrane potential; inhaled anesthetics, malignant hyperthermia
Isoflurane
Activate K+, block Na+, disrupt membrane potential; inhaled anesthetics, malignant hyperthermia
Ketamine
Block NDMA rec. dissociative anesthesia
Etomidate
IV anesthetic
Propofol
GABA channels, rapid onset/recovery
Procain
Local anesthetic (blocks activated and inactivated Na+ channels)
Tetracaine
Local anesthetic (blocks activated and inactivated Na+ channels)
Benzocaine
Local anesthetic (blocks activated and inactivated Na+ channels)
Lidocaine
Local anesthetic (blocks activated and inactivated Na+ channels)
Mepivacaine
Local anesthetic (blocks activated and inactivated Na+ channels)
Bupivacaine
Local anesthetic (blocks activated and inactivated Na+ channels)
Chlordiazepoxide
BZD, metabolites, anxiolytic
Diazepam (Valium)
BZD, metabolites, anxiolytic
Flurzaepam
BZD, hypnotic, metabolites
Clorazepate
BZD, metabolites, anxiolytic
Quazepam
BZD, hypnotic, metabolites
Alprazolam (Xanax)
BZD, anxiolytic and anesthetic
Lorazepam
BZD, metabolites, hypnotic
Clonazepam
BZD, anticonvulsant
Oxazepam
BZD, anxiolytic, EtOH withdrawal
Temazepam
BZD, anxiolytic, EtOH withdrawal
Estrazolam
BZD, short term hypnotic
Midazolam
BZD, rapid anesthesia
Triazolam
BZD, short term hypnotic
Flumazenil
BZD ant. BZD overdose
Zolpidem (Ambien)
Z-drug, insomnia, bind A1 subunit of BZ1 site
Zaleplon (Sonata)
Z-drug, insomnia, bind A1 subunit of BZ1 site
Eszopiclone (Lunesta)
Z-drug, insomnia, bind A1 subunit of BZ1 site
Phenobarbital
Barbiturate, anticonvulsant
Mephobarbital
Barbiturate, anticonvulsant
Amobarbital
Barbiturate, sedative-hypnotic
Butabarbital
Barbiturate, sedative-hypnotic
Pentobarbital
Barbiturate, sedative-hypnotic
Secobarbital
Barbiturate, sedative-hypnotic
Aprobarbital
Barbiturate, sedative-hypnotic
Thiopental
Barbiturate, IV anesthetic
Methohexital
Barbiturate, IV anesthetic
Thiamylal
Barbiturate, IV anesthetic
Ramelteon
MT1 and MT2 ag. works on circardian cycles, sleep
GHB
GABA-A,B,? narcolepsy
Buspirone
Partial 5HT1A ag. GAD, socail anxiety
Clomipramine
Partial SERT inh. TCA
Hydroxyzine
H1 ant, anxiolytic
Phenytoin
Na+ blocker, partial/tonic clonic
Fosphenytoin
Na+ blocker, partial/tonic-clonic
Carbmazepine
All Sz’s except absense, Na+ blocker
Oxcarbamazepine
Partial, Na+ blocker
Phenobarbital
Partial/tonic-clonic
Primidone
All but absence
Gabapentin
Partial, inc. GABA and Ca++ blocker
Pregablin (Lyrica)
Neuropathic pain, increase GABA
Vigbatrin (Sabile)
Adjunct for refractory Sz’s, Irr inh. of GABA transaminase
Tiagabine
Partial/tonic-clonic, Inh. GAT-1
Lacosmaine
Partial, Na+ blocker
Rufinamine
Partial and Lennox-Gastaut syndrome
Lamotrigine (Lamictal)
Partial, Na+ channel blocker
Zonisamide (Zonegram)
Partial in children
Levetiraceptam (Keppra)
Partial, GABA and Ca++
Felbamate
Partial, NDMA ant
Topiramate (Topamax)
Partial/tonic-clonic, AMAP ant.
Ethosuximide
Absence, T-type Ca++ blocker
Valproic acid (Depakote)
Absense, partial, generalized, bipolar; Na+, Ca++, GABA
Valproate
Tonic/clonic, absence, Na+
Codeine
Weak analgesic, good antitussive
Morphine
Sever, acute, chronic pain
Hydromorphone
Severe pain
Oxymorphone
Severe pain
Levophanol
Severe pain
Apomorphine
Severe pain
Hydrocodone
Moderate pain
Oxycodone
Moderate/severe pain
Dextromethorphan
good antitussive no analgesic
Heroin
Illegal
Meperidine (Demerol)
Analgesia Mu agonist
Propoxyphene (Davon)
Mild/moderate pain, weak Mu agonist
Methadone
Pain and addiction, Mu ag
Tramadol
Analgesia, weak Mu ag
Ketorolac (Toradol)
NSAID, severe pain
Tapentadol (Nucynta)
Pain, weak Mu ag
Methotrimeprazine
Pain, increases theshold and creates amnesia
Fentanyl
Severe pain, Mu agonist
Sufentanil
Severe pain, Mu agonist
Alfentanil
Severe pain, Mu agonist
Remifentanil (Ultiva)
Severe pain, selective Mu agonist
Diphenoxylate with atropine (Lomotil)
Diarrhea, Mu and Delta ant
Difenoxin with atropine (Motofen)
Diarrhea, Mu and delta ant
Loperamine (Imodium AD)
diarrhea, Mu and delta ant
Buprenophine (Buprenex, Subutex)
Opioid withdrawal, partial Mu agonist, weak kappa ag and delta ant
Butorphanol (Staldol)
Moderate to severe pain, strong kappa agonist, partial mu agonist
Nalbuphine (Nubain)
Mod/severe pain K ag mu ant
Pentazocine (Talwin)
mild/mod pain; kappa ag partial mu ag
Dezocine (Dulgan)
severe pain, parial mu agonist
Pentazocine with naloxone
Severe pain
Naloxone
Opioid OD, mu ant
Naltrexone
Heroin addiction and EtOH dependence, opioid receptor ant
Nalmefene
Alcohol dependence, opioid receptor ant
Fomepizole
Methanol/ethylene glycol poisoning
Disulfiram
Aldehyde dehydrogenase inh. alcoholism
Acamprosate
NMDA ant. reduced withdrawal from EtOH
x

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