Medchem test 2

myasthenia gravis results in…
destruction of ACh receptors at NM junction
botox results in
blocking of ACh release
small acyl group is good for
agonistic action
increasing acyl group size increases
antagonistic effects
alkyl substitutions on Beta carbon decreases _______ action
nicotinic
increasing ______ on amine group will change compound from agonist to antagonist
alkylation
_____ is identical to acetylcholine except the CH3 is replaced with an NH2
carbachol
can reduce intraocular pressure when pilocarpine or neostigmine fail
carbachol
pilocarpine treats _____ by _____
glaucoma; better draining of ocular fluid through canal of schlemn
indirect cholinergic agents work by?
blocking action of acetylcholinesterase
31 pairs of nerves
spinal nerves
cranial nerves
12 pair
carry impulses from periphery to CNS
sensory / afferent nerves
impulses from CNS to periphery
motor / efferent nerves
parasympathetic nervous system – where it comes out
craniosacral
sympathetic nervous system – where it comes out
thoracolumbar
parasympathetic has _____ preganglionic axons
long
sympathetic has ____ preganglinoic axons
short
first neurotransmitter released from spinal cord in autonomic system
ACh
connection between 2 neurons
synapse
connection between neuron and innervated tissue
junction
excitatory CNT release results in ______ of postsynaptic cell
depolarization
inhibitory CNT release results in ______ of post synaptic membrane
hyperpolarization
action of CNT terminated by THREE major mechanisms
uptake, metabolism, diffusion
cholinergic nerves result in ____ of GI tract
peristalsis
cholinergic nerves regulate _______ and ______ of the heartbeat
contraction and force
acetylcholine comes from
diet
butyrylcholinesterase is primarily found in ____
RBC or blood supply
first receptor ACh interacts with is _______
nicotinic
trimethylamine group is a better inhibitor in the ____ position than the ____ position
meta ; para
alzheimers results in reduced _______ receptor levels
nicotinic
enzyme responsible for biosynthesis of ACh
choline acetytransderase
aricept/donepezil is metabolized to an active phenol by _______
O-demethylation
phosphate esters are capable of
covalent bond formation
organophosphates cause ACh to ______ at nerve endings
accumulate
_____ is used to reverse the effects of nerve agents or insecticides
atropine
postganglionic neurotransmitter in sympathetic system
epinephrine or norepinephrine
postganglionic neurotransmitter in parasympathetic neuron
ACh
mydriatic effect
pupil dilation
anticholinergics ____ secretion of saliva and gastric juices
decrease
tiotropium/Spiriva blocks __ receptors in the airways
M3
x

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