Pharmacology

IBW equation
50 + (2.3 x Height in Inches over 60)

45 + (2.3 x Height in Inches over 60)

ABW equation
ABW=IBW + 0.4 (TBW – IBW)
BSA m2 equation
square root of ht(cm)x Wt(kg)/3,600
what equation is used to calculate the CrCl ml/min?
Cockcroft-Gault equation

(140-age)(Wt Kg)/(72)(SrCr mg/dl)

What are the normal values for CrCl in men and women
Normal CrCl
97-137 ml/min males
88-128 ml/min females
Renal dysfunction
<60ml/min
What is the normal creatinine levels in men and women
Normal creatinine in men 0.8 to 1.3 mg/dl and in women: 0.6 to 1.0 mg/dl.
What is the Volume of Distribution equation
Vd L = dose/ C0 or Cl/K
The elimination rate constant equation
-K = ln(C1/C0)/t1-t0
Half-life equation
t ? hr= 0.693/Kd
Or
t ? hr= (0.693)(Vd)/Cl
What is the SS Steady State?
Point at which, after multiple doses, amount of drug administered over a dosing interval equals amount of drug being eliminated over that same period
Which body weight should you use to calculate CrCl
IBW unless the person is OBESE, then use the adjusted body weight
what’s the criteria for being obese
if your actual body weight is 20% greater than your IBW
What can you say about a drug that has a high Vd(L)
the drug is lipophillic
What can you say about a drug that has a low Vd(L)
the drug is hydrophillic
if you double the dose and the concentration doubles, what order drug is it?
1st order
describe 1st order drugs
The fraction of the drug eliminated is constant
Describe Zero order drugs
The AMOUNT of Drug eliminated over time is constant
What is CrCl and indicator of?
of how well your kidneys are working
x

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